Al-Huniti, Nidal H.: search on Z-Library

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1

Population Pharmacokinetic and Pharmacodynamic Modeling of AZD4901 and Simulation to Support Dose Selection for the Phase 2a Study

Xu, Hongmei, Li, Jianguo, Webber, Lorraine, Kakkar, Rahul, Chen, Yingxue, Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 730 KB

english, 2016

2

Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children

Zhou, Wangda, Johnson, Trevor N., Bui, Khanh H., Cheung, S.Y. Amy, Li, Jianguo, Xu, Hongmei, Al-Huniti, Nidal, Zhou, Diansong

Journal:

Clinical Pharmacology & Therapeutics

Year:

2017

Language:

english

File:

PDF, 1.56 MB

english, 2017

3

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

Nayak, Satyaprakash, Sander, Oliver, Al-Huniti, Nidal, de Alwis, Dinesh, Chain, Anne, Chenel, Marylore, Sunkaraneni, Soujanya, Agrawal, Shruti, Gupta, Neeraj, Visser, Sandra A.G.

Journal:

Clinical Pharmacology & Therapeutics

Year:

2018

Language:

english

File:

PDF, 220 KB

english, 2018

4

Bridging Olaparib Capsule and Tablet Formulations Using Population Pharmacokinetic Meta-analysis in Oncology Patients

Zhou, Diansong, Li, Jianguo, Bui, Khanh, Learoyd, Maria, Berges, Alienor, Milenkova, Tsveta, Al-Huniti, Nidal, Tomkinson, Helen, Xu, Hongmei

Journal:

Clinical Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

5

Population Pharmacokinetics of the BTK Inhibitor Acalabrutinib and its Active Metabolite in Healthy Volunteers and Patients with B-Cell Malignancies

Edlund, Helena, Lee, Sun Ku, Andrew, Marilee A., Slatter, J. Greg, Aksenov, Sergey, Al-Huniti, Nidal

Journal:

Clinical Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 1.20 MB

english, 2018

6

Efficacy and Safety Exposure-Response Analyses of Olaparib Capsule and Tablet formulations in Oncology Patients

Zhou, Diansong, Li, Jianguo, Learoyd, Maria, Bui, Khanh, Berges, Alienor, Milenkova, Tsveta, Al-Huniti, Nidal, Tomkinson, Helen, Xu, Hongmei

Journal:

Clinical Pharmacology & Therapeutics

Year:

2018

Language:

english

File:

PDF, 1.05 MB

english, 2018

7

Physiologically-Based Pharmacokinetic Modelling to Predict Exposure Differences in Healthy Volunteers and Subjects with Renal Impairment: Ceftazidime Case Study

Zhou, Li, Tong, Xiao, Sharma, Pradeep, Xu, Hongmei, Al-Huniti, Nidal, Zhou, Diansong

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2019

Language:

english

File:

PDF, 516 KB

english, 2019

8

Population pharmacokinetic analysis of esomeprazole in Japanese subjects with various CYP2C19 phenotypes

Nagase, Mario, Shimada, Hitoshi, Nii, Masahiro, Ueda, Shinya, Higashimori, Mitsuo, Ichikawa, Katsuomi, Zhang, Li, Zhou, Li, Chen, Yingxue, Zhou, Diansong, Dunyak, James, Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacy and Therapeutics

Year:

2020

Language:

english

File:

PDF, 1.47 MB

english, 2020

9

Pharmacodynamic Analysis of Changes in Reticulocyte Subtype Distribution in Phlebotomy-Induced Stress Erythropoiesis

Nidal H. Al-Huniti, John A. Widness, Robert L. Schmidt, Peter Veng-Pedersen

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2005

Language:

english

File:

PDF, 241 KB

english, 2005

10

Hypercholesterolemia is a Potential Risk Factor for Asthma

Al-Shawwa, Baha, Al-Huniti, Nidal, Titus, Gregory, Abu-Hasan, Mutasim

Journal:

Journal of Asthma

Year:

2006

Language:

english

File:

PDF, 90 KB

english, 2006

11

Asthma and Insulin Resistance in Morbidly Obese Children and Adolescents

Al-Shawwa, Baha A., Al-Huniti, Nidal H., DeMattia, Laure, Gershan, William

Journal:

Journal of Asthma

Year:

2007

Language:

english

File:

PDF, 170 KB

english, 2007

12

Population pharmacokinetics of TC-5214, a nicotinic channel modulator, in phase I and II clinical studies

Xu, Hongmei, Henningsson, Anja, Alverlind, Sofie, Tummala, Raj, Toler, Steven, Beaver, Jessica S., Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

13

Respiratory Syncytial Virus Bronchiolitis and Risk of Subsequent Wheezing: A Matter of Severity

Al-Shawwa, Baha, Al-Huniti, Nidal, Abu-Hasan, Mutasim

Journal:

Pediatric Asthma Allergy & Immunology

Year:

2006

Language:

english

File:

PDF, 74 KB

english, 2006

14

Reporting guidelines for population pharmacokinetic analyses

Dykstra, Kevin, Mehrotra, Nitin, Tornøe, Christoffer Wenzel, Kastrissios, Helen, Patel, Bela, Al-Huniti, Nidal, Jadhav, Pravin, Wang, Yaning, Byon, Wonkyung

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2015

Language:

english

File:

PDF, 644 KB

english, 2015

15

Effects of CYP3A Modulators on the Pharmacokinetics of Naloxegol

Bui, Khanh, Zhou, Diansong, Sostek, Mark, She, Fahua, Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 246 KB

english, 2015

16

Population pharmacokinetic modeling of quetiapine after administration of seroquel and seroquel XR formulations to Western and Chinese patients with schizophrenia, schizoaffective disorder, or bipolar disorder

Zhou, Diansong, Bui, Khanh H., Li, Jianguo, Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 1022 KB

english, 2015

17

The effect of quinidine, a strong P-glycoprotein inhibitor, on the pharmacokinetics and central nervous system distribution of naloxegol

Bui, Khanh, She, Fahua, Zhou, Diansong, Butler, Kathleen, Al-Huniti, Nidal, Sostek, Mark

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 274 KB

english, 2016

18

Reply to: Letter to the Editor “Effect of Quinidine, a Strong P-Glycoprotein Inhibitor, on the Pharmacokinetics and Central Nervous System Distribution of Naloxegol”

Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 59 KB

english, 2016

19

Reporting guidelines for population pharmacokinetic analyses

Dykstra, Kevin, Mehrotra, Nitin, Tornøe, Christoffer Wenzel, Kastrissios, Helen, Patel, Bela, Al-Huniti, Nidal, Jadhav, Pravin, Wang, Yaning, Byon, Wonkyung

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 417 KB

english, 2015

20

Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients

Al-Huniti, Nidal, Chapel, Sunny, Xu, Hongmei, Bui, Khanh H., Sostek, Mark

Journal:

British Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 3.57 MB

english, 2016

21

Evaluation of Aztreonam Dosing Regimens in Patients with Normal and Impaired Renal Function: A Population Pharmacokinetic Modeling and Monte Carlo Simulation Analysis

Xu, Hongmei, Zhou, Wangda, Zhou, Diansong, Li, Jianguo, Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.79 MB

english, 2016

22

Model evaluation of continuous data pharmacometric models: Metrics and graphics

Nguyen, Thi-Huyen-Tram, Mouksassi, Mohamad-Samer, Holford, Nick, Al-Huniti, Nidal, Freedman, Immanuel, Hooker, Andrew C., John, Jyothy, Karlsson, Mats O., Mould, Diane R., Pérez Ruixo, Juan José, Plan

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2016

Language:

english

File:

PDF, 2.80 MB

english, 2016

23

Clinical Pharmacokinetics and Pharmacodynamics of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist

Bui, Khanh, Zhou, Diansong, Xu, Hongmei, Floettmann, Eike, Al-Huniti, Nidal

Journal:

Clinical Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 863 KB

english, 2017

24

Evaluation of the Effect of Selumetinib on Cardiac Repolarization: A Randomized, Placebo- and Positive-controlled Crossover QT/QTc Study in Healthy Subjects

Zhou, Diansong, So, Karen, Dymond, Angela W., Vik, Torbjorn, Al-Huniti, Nidal, Mariani, Gabriella, Zorenyi, Gyorgy, Huang, Yifan, Holmes, Victoria, Severin, Paul, Rasmussen, Scott, Martin, Paul

Journal:

Clinical Therapeutics

Year:

2016

Language:

english

File:

PDF, 321 KB

english, 2016

25

Population pharmacokinetic and exposure simulation analysis for cediranib (AZD2171) in pooled Phase I/II studies in patients with cancer

Li, Jianguo, Al-Huniti, Nidal, Henningsson, Anja, Tang, Weifeng, Masson, Eric

Journal:

British Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 628 KB

english, 2017

26

Development of a physiologically based pharmacokinetic model to predict the effects of Flavin-Containing Monooxygenase 3 (FMO3) polymorphisms on Itopride exposure

Zhou, Wangda, Humphries, Helen, Neuhoff, Sibylle, Gardner, Iain, Masson, Eric, Al-Huniti, Nidal, Zhou, Diansong

Journal:

Biopharmaceutics & Drug Disposition

Year:

2017

Language:

english

File:

PDF, 510 KB

english, 2017

27

Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet

Helmlinger, Gabriel, Al-Huniti, Nidal, Aksenov, Sergey, Peskov, Kirill, Hallow, Melissa, Chu, Lulu, Boulton, David, Eriksson, Ulf, Hamrén, Bengt, Lambert, Craig, Masson, Eric, Tomkinson, Helen, Stansk

Journal:

European Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 1.29 MB

english, 2017

28

Population Pharmacokinetic Analysis of Zolmitriptan and Its Metabolite in Adults and Adolescents to Support Dose Selection in Children With Migraine

Zhou, Wangda, Li, Jianguo, Birmingham, Bruce, Xu, Hongmei, Lillieborg, Stefan, Zhou, Diansong, Al-Huniti, Nidal

Journal:

Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 720 KB

english, 2017

29

Population Exposure-Response Modeling Supported Selection of Naloxegol Doses in Phase 3 Studies in Patients with Opioid Induced Constipation

Al-Huniti, Nidal, Xu, Hongmei, Zhou, Diansong, Aksenov, Sergey, Fox, Robert, Bui, Khanh H.

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.95 MB

english, 2017

30

Physiologically Based Pharmacokinetic Modeling to Evaluate the Systemic Exposure of Gefitinib in CYP2D6 Ultrarapid Metabolizers and Extensive Metabolizers

Chen, Yingxue, Zhou, Diansong, Tang, Weifeng, Zhou, Wangda, Al-Huniti, Nidal, Masson, Eric

Journal:

Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 418 KB

english, 2017

31

Integrating dose estimation into a decision-making framework for model-based drug development

Dunyak, James, Mitchell, Patrick, Hamrén, Bengt, Helmlinger, Gabriel, Matcham, James, Stanski, Donald, Al-Huniti, Nidal

Journal:

Pharmaceutical Statistics

Year:

2018

Language:

english

File:

PDF, 659 KB

english, 2018

32

Assessing QT/QTc interval prolongation with concentration-QT modeling for Phase I studies: impact of computational platforms, model structures and confidence interval calculation methods

Lu, Jingtao, Li, Jianguo, Helmlinger, Gabriel, Al-Huniti, Nidal

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2018

Language:

english

File:

PDF, 861 KB

english, 2018

33

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Kosinsky, Yuri, Dovedi, Simon J., Peskov, Kirill, Voronova, Veronika, Chu, Lulu, Tomkinson, Helen, Al-Huniti, Nidal, Stanski, Donald R., Helmlinger, Gabriel

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2018

Language:

english

File:

PDF, 3.30 MB

english, 2018

34

Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy

Tong, Xiao, Zhou, Diansong, Savage, Alicia, Mullen, Jamie A., Li, Yan, Taylor, Wendy, Li, Jianguo, Al-Huniti, Nidal, Xu, Hongmei

Journal:

Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 859 KB

english, 2018

35

Simplified aztreonam dosing in patients with end stage renal disease: results of a Monte Carlo simulation

Gross, Alan E, Xu, Hongmei, Zhou, Diansong, Al-Huniti, Nidal

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2018

Language:

english

File:

PDF, 819 KB

english, 2018

36

Population Pharmacokinetic and Exposure-Response Analysis of Selumetinib and Its N-desmethyl Metabolite in Patients With Non-Small Cell Lung Cancer

Tong, Xiao, Xu, Hongmei, Carlile, David J., Tomkinson, Helen, Al-Huniti, Nidal, Zhou, Diansong

Journal:

Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 751 KB

english, 2018

37

Joint longitudinal and time-to-event models for multilevel hierarchical data

Brilleman, Samuel L, Crowther, Michael J, Moreno-Betancur, Margarita, Buros Novik, Jacqueline, Dunyak, James, Al-Huniti, Nidal, Fox, Robert, Hammerbacher, Jeff, Wolfe, Rory

Journal:

Statistical Methods in Medical Research

Year:

2018

Language:

english

File:

PDF, 531 KB

english, 2018

38

Resistance models to EGFR inhibition and chemotherapy in non-small cell lung cancer via analysis of tumour size dynamics

Mistry, Hitesh B., Helmlinger, Gabriel, Al-Huniti, Nidal, Vishwanathan, Karthick, Yates, James

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2019

Language:

english

File:

PDF, 1.29 MB

english, 2019

39

Assessing pharmacokinetic differences in Caucasian and East Asian (Japanese, Chinese and Korean) populations driven by CYP2C19 polymorphism using physiologically-based pharmacokinetic modelling

Zhou, Li, Sharma, Pradeep, Yeo, Karen Rowland, Higashimori, Mitsuo, Xu, Hongmei, Al-Huniti, Nidal, Zhou, Diansong

Journal:

European Journal of Pharmaceutical Sciences

Year:

2019

Language:

english

File:

PDF, 1.18 MB

english, 2019

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